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Philby et al., Scientific Reports, 2017

Reduced Regional Grey Matter Volumes in Paediatric Obstructive Sleep Apnoea

Focus & Behaviour
Published 2017

This study used brain scans to compare children with sleep apnoea to healthy children — and what they found is alarming. Children who weren't breathing properly at night had less brain matter in several important areas, especially the parts of the brain responsible for decision-making, attention, and controlling emotions.

The damage wasn't subtle. Roughly 35,000 tiny regions of the brain showed significant differences — concentrated in the front of the brain, the area that helps children focus, plan, and regulate their impulses.

What makes this finding so important is that it shows sleep apnoea in children doesn't just make them tired. It can cause real, measurable changes to the structure of the developing brain. The younger the brain, the more vulnerable it is — and these changes may not be easily reversed once the critical growth window has passed.

Key Findings

  • Grey matter volume reductions across the prefrontal cortex and brainstem in children with OSA.

  • ~35,000 voxels of brain tissue showed statistically significant volume loss (P < 0.05, FWE-corrected).

  • Left-hemisphere dominance in volume reductions, particularly in the superior temporal lobe.

Source

Philby et al., Scientific Reports, 2017

DOI: 10.1038/srep44566

Added to the Evidence Hub: 10 January 2026